My wheelchair is from Duro-Med Industries s/no. KS-06315 tire size 12 1/2 X 2 1/4 will your tire fit?
We don't have known compatibility for that particular model. This wheel was made for Drive brand transport chairs and measures 12" in diameter, 1.75" in width, and has 6001Z bearings.
As you indicated the tires you are looking for are 12.5" x 2.25", it does not appear that this caster wheel would be compatible with your unit. However, if the bearing size matches those on your current caster wheels and you wanted to try replacing both original caster wheels with these ones, they can be returned within 60 days in new/unused/undamaged condition if they don't work for you.